We are investigating the origins of blood stem cell generation in the embryo. We are interesting in profiling ontogeny and reprogramming non-blood cells into blood cells Origins and ontogeny of blood in the mammalian embryo (Diagram courtesy of JIm Palis, … Read More
Transcriptional Regulation of Haemoglobin switching We employ genomics techniques (ChIp-Seq, RNA-Seq, SLAM-Seq), biochemical techniques (EMSA, SPR) and genetics techniques (CRISPR/CAS9 gene editing) to examine the role of transcription factors in red blood cell differentiation and diseases Supervisors: Kevin Gillinder and … Read More
High throughput Next Generation Sequencing (NGS) is becoming increasing important in the routine diagnosis and molecular monitoring of cancer. The myeloproliferative neoplasms (MPNs) are a heterogeneous group of blood disorders characterised by unrestrained proliferation of mature blood cell types. Unlike the … Read More
CRISPR-Cas9 genome editing is a revolutionary technology that allows rapid and precise modification of the eukaryotic genome. Developed in 2013, the technology has exploded, with over 1000 published articles using the technology. Given the simplicity and efficiency of the technology, our … Read More