Melissa Ilsley, Steven Huang, Charles Bell, Graham Magor, Michael Landsberg, Kevin Gillinder#, and Andrew Perkins#. Corrupted DNA-binding specificity and ectopic transcription underpin dominant neomorphic mutations in KLF/SP transcription factors. BMC Genomics (2019)  May 24;20(1):417 #, co-senior authors.
HIF prolylhydroxylase inhibitor FG-4497 enhances mouse hematopoietic stem cell mobilization in part via VEGFR2/KDR. Kavita Bisht, Marion E Brunck, Taichi Matsumoto, Crystal McGirr, Bianca Nowlan, Whitney Fleming, Thomas Keech, Graham Magor, Andrew Perkins, Julie Davies, Gail Walkinshaw, Lee Flippin, Ingrid G Winkler, Jean-Pierre Levesque. Blood Advances (2019) Feb 12 3(3): 406-418
Nicole S. Fraser, Christine M. Knauth , Elizna M. Schoeman, Melinda M. Dean, Assia Moussa, Andrew C. Perkins, Catherine A. Hyland, and Robert L. Flower. Genetic variants within the erythroid transcription factor, KLF1, and reduction of the expression of Lutheran and other blood group antigens: review of the In(Lu) phenotype. Transfusion Medicine Reviews (2019) Apr;33(2):111-117
Forsyth CJ, Chan WH, Grigg AP, Cook NC, Lane SW, Burbury KL, Perkins AC, Ross DM. Recommendations for the use of Pegylated Interferon-α in The Treatment Of Classical Myeloproliferative Neoplasms.  Internal Medicine J. (2018) 2018 Nov 8. doi: 10.1111/imj.14154. [Epub ahead of print].
Danitza Nebor, Joel H Graber, Steven L Ciciotte, Raymond F Robledo, Julien Papoin, Emily Hartman, Kevin R Gillinder, Andrew C Perkins, James J Bieker, Lionel Blanc, and Luanne L Peters. Mutant KLF1 in Adult Anemic Nan Mice Leads to Profound Transcriptome Changes and Disordered Erythropoiesis.  Scientific Reports (2018) Aug 24;8(1):12793
Fraser N, Knauth C, Moussa A, Perkins AC, Dean M, Millard G, Flower R, and Hyland C. Investigation of the variable In(Lu) phenotype caused by KLF1Transfusion (2018) 58(10):2414-2420
Simranpreet Kaur, Liza J. Raggatt, Cameron Sunderland, Susan Millard, Andy C. Wu, Lena Batoon, Rebecca N. Jacobsen, Ingrid G. Winkler, Kelli P. MacDonald, Andrew C. Perkins, David A. Hume, Jean-Pierre Levesque and Allison R. Pettit. Self-repopulating recipient bone marrow resident macrophages promote hematopoietic stem cell engraftment.  Blood (2018) Aug 16;132(7):735-749
Karen S. Cheung Tung Shing, Sophie E. Broughton, Tracy L. Nero, Kevin Gillinder, Melissa D Ilsley, Angel F. Lopez, Michael D. W. Griffin, Michael W. Parker, Andrew C. Perkins, Urmi Dhagat. EPO does not promote interaction between the erythropoietin and beta-common receptors. Scientific Reports (2018) Aug 20;8(1):12457
Gillinder K, Magor G and Perkins ACVariable serological and other phenotypes due to KLF1 mutations. Transfusion (2018) May;58(5):1324-1325
Hao Lu, Maria C. Rondón Galeano, Elisabeth Ott, Geraldine Kaeslin, Jaya P. Kausalya, Carina Kramer, Nadina Ortiz-Brüchle, Nadescha Hilger, Vicki Metzis, Milan Hiersche, Shang Yew Tay, Robert Tunningley, Shubha Vij, Andrew D Courtney, Belinda Whittle, Elke Wühl, Udo Vester, Björn Hartleben, Steffen Neuber, Valeska Frank, Melissa H Little, Daniel Epting, Peter Papathanasiou, Andrew C Perkins, Walter Hunziker, HY Gee, Klaus Zerres, Friedhelm Hildebrandt, Sudipto Roy, Carol Wicking and Carsten Bergmann. Mutations in DZIP1L, which encodes a ciliary transition zone protein, cause autosomal recessive polycystic kidney disease Nature Genetics (2017) 49 (7): 1025-103
Suzanne O. Arulogun, Hock-Choong Lai, Debbie Taylor, Paula Ambrosoli, Graham Magor, Ian M. Irving, Tee-Beng Keng, and Andrew C. Perkins. JAK1 somatic mutation in a myeloproliferative neoplasm. Haematologica (2017) Aug; 102 (8): e324-e327
Brian S. Gloss, Bethany Signal, Seth W. Cheetham, Franziska Gruhl, Dominik Kaczorowski, Andrew C. Perkins, Marcel E. Dinger. High resolution temporal transcriptomics of mouse embryoid body development reveals complex expression dynamics of coding and noncoding loci.  Scientific Reports (2017) Jul 27;7(1): 6731
Ilsley, Melissa D; Gillinder, Kevin R; Magor, Graham W; Huang, Stephen; Bailey, Timothy L; Crossley, Merlin; Perkins, Andrew C. Krüppel-like factors compete for promoters and enhancers to fine-tune transcription. Nucleic Acids Research (2017). 45:11:6572–6588
Gillinder, Kevin R; Tuckey, Hugh; Bell, Charles C; Magor, Graham W; Huang, Stephen; Ilsley, Melissa D; Perkins, Andrew C. Direct targets of pSTAT5 signalling in erythropoiesis. PloS one (2017). 12:7-e0180922
Mesa, Ruben A; Vannucchi, Alessandro M; Mead, Adam; Egyed, Miklos; Szoke, Anita; Suvorov, Aleksandr; Jakucs, Janos; Perkins, Andrew; Prasad, Ritam; Mayer, Jiri. Pacritinib versus best available therapy for the treatment of myelofibrosis irrespective of baseline cytopenias (PERSIST-1): an international, randomised, phase 3 trialLancet Haematology (2017) May;4(5): e225-e236
Ho, P Joy; Bajel, Ashish; Burbury, Kate; Dunlop, Lindsay; Durrant, Simon; Forsyth, Cecily; Perkins, Andrew C; Ross, David M. A case‐based discussion of clinical problems in the management of patients treated with ruxolitinib for myelofibrosisInternal Medicine Journal 47:3-262-268 (2017). http://dx.doi.org/10.1111/imj.13341
Planutis, Antanas; Xue, Li; Trainor, Cecelia D; Dangeti, Mohan; Gillinder, Kevin; Siatecka, Miroslawa; Nebor, Danitza; Peters, Luanne L; Perkins, Andrew C; Bieker, James J. Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development. Development (2017)144:3:430-440
Lackey, Alan; Laing, Barbara; Perkins, Andrew; Bryant, Michael. Diagnosis in subdural myeloid sarcoma. The Neuroradiology Journal  (2017) 1971400916689340
Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability.
Kevin R. Gillinder, Melissa D. Ilsley, Danitza Nébor, Ravi Sachidanandam, Mathieu Lajoie, Graham W. Magor, Michael R. Tallack, Timothy Bailey, Michael J. Landsberg, Joel Mackay, Michael W. Parker, Luke A. Miles, Joel H. Graber, Luanne L. Peters, James J. Bieker and Andrew C. Perkins. Nucleic Acids Research (2017) 45(3): 1130-1143 

Andrew Perkins, Xiangmin Xu, Douglas R. Higgs, The KLF1 Consensus Workgroup, George P. Patrinos, Lionel Arnaud, James J. Bieker and Sjaak Philipsen. Kruppeling Erythropoiesis: The increasing importance of DNA sequencing in human genetic disease illustrated by variants of a master regulator of erythropoiesis. Blood (2016) 127(15):1856-62
Jacobsen R, Perkins AC and Levesque J-P. Macrophages and regulation of erythropoiesis.  Current Opinion in Hematology (2015) 22(3):212-9.
Graham W. Magor, Michael R. Tallack, Nathan M. Klose, Debbie Taylor, Darren Korbie, Peter Mollee, Matt Trau and Andrew C. Perkins. Rapid molecular profiling of myeloproliferative neoplasms using targeted exon re-sequencing of 86 genes involved in JAK-STAT signalling and epigenetic regulation. Journal of Molecular Diagnostics (2016) Sep; 18(5):707-18
Max Gulhane, Lydia Murray, Ran Wang, Hui Ton, Jakob Begun, Graham Magor, Tim Florin, Andrew Perkins, Michael McGuckin and Sumaira Hasnain. High fat diet and the colonic mucus barrier: Implications for Obesity and Inflammatory Bowel Disease. Scientific Reports (2016) Jun 28; 6:28990
Charles C. Bell, Paulo P. Amaral, Anton Kalsbeek, Graham W. Magor, Kevin R. Gillinder, Pierre Tangermann, Lorena di Lisio, Seth W. Cheetham, Franziska Gruhl, Jessica Frith, Michael R. Tallack, Ke-Lin Ru, Joanna Crawford, John S. Mattick, Marcel E. Dinger, and Andrew C. Perkins. The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulation. Scientific Reports (2016) May 26; 6:26657.

Jacobsen, Rebecca N., Andrew C. Perkins, and Jean-Pierre Levesque. Macrophages and regulation of erythropoiesis. Current Opinion in Hematology (2015) 22(3):212-9
Kaur, Simranpreet, Liza J. Raggatt, Rebecca Jacobsen, Susan Millard, Valerie Barbier, Bianca Nowlan, Ingrid G. Winkler et al. Autologous haematopoietic stem cell transplantation requires recipient BM macrophages. Experimental Hematology 43, no. 9 (2015): S71.
Magor, Graham W., Michael R. Tallack, Kevin R. Gillinder, Charles C. Bell, Naomi McCallum, Bronwyn Williams, and Andrew C. Perkins. KLF1 null neonates display hydrops fetalis and a deranged erythroid transcriptome. Blood (2015) 125(15):2405-17.
Sorolla, Anabel, Michael R. Tallack, Harald Oey, Sarah K. Harten, Lucia Clemens-Daxinger, Graham W. Magor, Alex N. Combes, Melissa Ilsley, Emma Whitelaw, and Andrew C. Perkins. Identification of novel hypomorphic and null mutations in Klf1 derived from a genetic screen for modifiers of α-globin transgene variegation. Genomics (2015) 105, no. 2 : 116-122.


Bell, Charles C., Graham W. Magor, Kevin R. Gillinder, and Andrew C. Perkins. A high-throughput screening strategy for detecting CRISPR-Cas9 induced mutations using next-generation sequencing. BMC Genomics (2014) 15:1002
Wang X, Mendelsohn L, Rogers H, Leitman S, Tallack M, Perkins AC, Taylor JG, Noguchi CT, Kato GJ.    Heme-Bound Iron Activates Placenta Growth Factor via Erythroid Krüppel‐like Factor in Erythroid Cells. Blood (2014) Aug 7;124(6):946-54.
Pattabiraman DR, Shakhbazov K, Barbier V, Krishnan K, Mukhopadhyay P, Grimmond SM, Papathanasiou P, Perkins AC, Alexander WS, Levesque J-P, Winkler, IG, and Gonda TJ. Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes. Blood (2014) Apr 24; 123(17):2682-90.


Tallack, Michael R., and Andrew C. Perkins. Three fingers on the switch: Krüppel-like factor 1 regulation of γ-globin to β-globin gene switching. Current Opinion in Hematology (2013) 20 (3):193-200
Alister P. W. Funnel, Ka Sin Mak, Natalie A. Twine, Gregory J. Pelka, Laura J. Norton, Tania Radziewic, Melinda Power, Marc R. Wilkins, Kim S. Bell-Anderson, Stuart T. Fraser, Andrew C. Perkins, Patrick P. Tam, Richard C. M. Pearson and Merlin Crossley. Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Mol Cel Biol. (2013) Aug; 33(15):2976-87.


Tallack, Michael R., Graham W. Magor, Benjamin Dartigues, Lei Sun, Stephen Huang, Jessica M. Fittock, Sally V. Fry, Evgeny A. Glazov, Timothy L. Bailey, and Andrew C. Perkins. Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq. Genome Research (2012) Dec; 22(12):2385-98.
Igor Kovacevic, Jiong Hu, Ann Siehoff-Icking, Nils Opitz, Aliesha Griffin, Andrew C. Perkins, Alan L. Munn, Werner Muller-Esterl, Rüdiger Popp, Benno Jungblut, Meike Hoffmeister, Stefanie Oess. The F‐BAR protein NOSTRIN participates in FGF signal transduction and vascular development. EMBO J. (2012) Aug 1;31(15):3309-22
Sun, Lei, Zhihua Zhang, Timothy L. Bailey, Andrew C. Perkins, Michael R. Tallack, Zhao Xu, and Hui Liu. Prediction of novel long non-coding RNAs based on RNA-Seq data of mouse Klf1 knockout study. BMC Bioinformatics (2012) Dec 13; 13(1):331.
Funnell AP, Norton LJ, Mak KS, Burdach J, Artuz CM, Twine NA, Wilkins MR, Power CA, Hung TT, Perdomo J, Koh P, Bell-Anderson KS, Orkin SH, Fraser ST, Perkins AC, Pearson RCM, and Crossley MP. The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo. Mol Cel Biol. (2012) Aug; 32(16):3189-92.


Van Zuylen, Wendy J., Valerie Garceau, Adi Idris, Kate Schroder, Katharine M. Irvine, Jane E. Lattin, Dmitry A. Ovchinnikov et al. “Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis.” PloS one 6, no. 1 (2011): e15723.


Tallack, Michael R., and Andrew C. Perkins. KLF1 directly coordinates almost all aspects of terminal erythroid differentiation. IUBMB LIFE (2010) 62 (12); 886-890
Tallack, Michael R., Tom Whitington, Wai Shan Yuen, Elanor N. Wainwright, Janelle R. Keys, Brooke B. Gardiner, Ehsan Nourbakhsh et al. “A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells.” Genome research 20, no. 8 (2010): 1052-1063.
Tallack, Michael R., and Andrew C. Perkins. “Megakaryocyte-erythroid lineage promiscuity in EKLF null mouse blood.” haematologica 95, no. 1 (2010): 144-147.
Papathanasiou, Peter, Robert Tunningley, Diwakar R. Pattabiraman, Ping Ye, Thomas J. Gonda, Belinda Whittle, Adam E. Hamilton, Simon O. Cridland, Rohan Lourie, and Andrew C. Perkins. “A recessive screen for genes regulating hematopoietic stem cells.” Blood 116, no. 26 (2010): 5849-5858.


Tallack, Michael R., Janelle R. Keys, Patrick O. Humbert, and Andrew C. Perkins. “EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2.” Journal of Biological Chemistry 284, no. 31 (2009): 20966-20974.
Tallack, Michael, Thomas Whitington, Brooke Gardiner, Eleanor Wainwright, Janelle Keys, Marion Monet, Ehsan Nourbakhsh et al. “Klf1 regulatory networks in primary erythroid cells.” In Blood, vol. 114, no. 22, pp. 591-591. American Society of Hematology, 2009.
Amaral, Paulo P., Christine Neyt, Simon J. Wilkins, Marjan E. Askarian-Amiri, Susan M. Sunkin, Andrew C. Perkins, and John S. Mattick. “Complex architecture and regulated expression of the Sox2ot locus during vertebrate development.” Rna 15, no. 11 (2009): 2013-2027.
Kassahn, Karin S., Vinh T. Dang, Simon J. Wilkins, Andrew C. Perkins, and Mark A. Ragan. “Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates.” Genome Research 19, no. 8 (2009): 1404-1418.
Whitington, Tom, Andrew C. Perkins, and Timothy L. Bailey. “High-throughput chromatin information enables accurate tissue-specific prediction of transcription factor binding sites.” Nucleic acids research 37, no. 1 (2009): 14-25.
Cridland, Simon O., Janelle R. Keys, Peter Papathanasiou, and Andrew C. Perkins. “Indian hedgehog supports definitive erythropoiesis.” Blood Cells, Molecules, and Diseases 43, no. 2 (2009): 149-155.


Keys, Janelle R., Michael R. Tallack, Ye Zhan, Peter Papathanasiou, Christopher C. Goodnow, Karin M. Gaensler, Merlin Crossley, Job Dekker, and Andrew C. Perkins. “A mechanism for Ikaros regulation of human globin gene switching.” British journal of haematology 141, no. 3 (2008): 398-406.
Cloonan, Nicole, Alistair RR Forrest, Gabriel Kolle, Brooke BA Gardiner, Geoffrey J. Faulkner, Mellissa K. Brown, Darrin F. Taylor et al. “Stem cell transcriptome profiling via massive-scale mRNA sequencing.” Nature methods 5, no. 7 (2008): 613-619.
Dinger, Marcel E., Paulo P. Amaral, Tim R. Mercer, Ken C. Pang, Stephen J. Bruce, Brooke B. Gardiner, Marjan E. Askarian-Amiri et al. “Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation.” Genome research 18, no. 9 (2008): 1433-1445.
Sue, Nancy, Briony HA Jack, Sally A. Eaton, Richard CM Pearson, Alister PW Funnell, Jeremy Turner, Robert Czolij et al. “Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis.” Molecular and cellular biology 28, no. 12 (2008): 3967-3978.
Wilkins, Simon J., Simon Yoong, Heather Verkade, Takamasa Mizoguchi, Sarah J. Plowman, John F. Hancock, Yutaka Kikuchi, Joan K. Heath, and Andrew C. Perkins. “Mtx2 directs zebrafish morphogenetic movements during epiboly by regulating microfilament formation.” Developmental biology 314, no. 1 (2008): 12-22.


Tallack, Michael R., Janelle R. Keys, and Andrew C. Perkins. “Erythroid Kruppel-like Factor Regulates the G1 Cyclin Dependent Kinase Inhibitor p18 INK4c.” Journal of molecular biology 369, no. 2 (2007): 313-321.
Funnell, Alister PW, Christopher A. Maloney, Lucinda J. Thompson, Janelle Keys, Michael Tallack, Andrew C. Perkins, and Merlin Crossley. “Erythroid Krüppel-like factor directly activates the basic Krüppel-like factor gene in erythroid cells.” Molecular and cellular biology 27, no. 7 (2007): 2777-2790.
Bruce, Stephen J., Robert W. Rea, Anita L. Steptoe, Meinrad Busslinger, John F. Bertram, and Andrew C. Perkins. “In vitro differentiation of murine embryonic stem cells toward a renal lineage.” Differentiation 75, no. 5 (2007): 337-349.
Pearson, R., A. P. W. Funnell, A. Kwok, J. Keys, M. Tallack, D. Hodge, A. C. Perkins, and M. Crossley. “The regulation of gene repression by BKLF.” Blood Cells, Molecules, and Diseases 38, no. 2 (2007): 133-134.
Perkins, Andrew C., Janelle R. Keys, Denise J. Hodge, and Michael R. Tallack. “Erythroid Kruppel-Like Factor Regulates E2F4 and the G1 Cdk Inhibitor, p18.” In ASH Annual Meeting Abstracts, vol. 106, no. 11, p. 1357. 2005.
Funnell, A. P. W., J. Keys, M. Tallack, D. Hodge, A. C. Perkins, and M. Crossley. “Identification of a novel, erythroid BKLF promoter.” Blood Cells, Molecules, and Diseases 38, no. 2 (2007): 139-140.
Keys, Janelle R., Michael R. Tallack, Denise J. Hodge, Simon O. Cridland, Rakesh David, and Andrew C. Perkins. “Genomic organisation and regulation of murine alpha haemoglobin stabilising protein by erythroid Kruppel‐like factor.” British journal of haematology 136, no. 1 (2007): 150-157.
Perkins, Andrew C., Michael Tallack, Ye Zhan, Peter Papathanasiou, Crhistopher Goodnow, Karin Gaensler, Paul M. Crossley, Job Dekker, and Janelle R. Keys. “Ikaros Drives Human Haemoglobin Switching by Facilitating Active Chromatin Hub Formation.” In ASH Annual Meeting Abstracts, vol. 110, no. 11, p. 1772. 2007.


Bruce, S., L. Rossiter, A. Steptoe, J. Deare, S. Ricardo, E. Naim, J. F. Bertram, and A. C. Perkins. “Kidney gene expression within mouse embryonic stem cells.” In Cytometry Part a, vol. 69, no. 5, pp. 415-415. Wiley-Liss, 2006.
van Vliet, Jane, Linda A. Crofts, Kate GR Quinlan, Robert Czolij, Andrew C. Perkins, and Merlin Crossley. “Human KLF17 is a new member of the Sp/KLF family of transcription factors.” Genomics 87, no. 4 (2006): 474-482.


2005 and older
Gardiner, Melissa R., Dave F. Daggett, Sharon L. Amacher, Peter D. Currie, Leonard I. Zon, and Andrew C. Perkins. “Zebrafish KLF4 is essential for hatching and haematopoiesis.” In Developmental Biology, vol. 283, no. 2, pp. 619-619. Elsevier, 2005.
Turner, Jeremy, Melissa Holmes, Robert Czoli, Karin Gaensler, Haidi Yang, Yuko Fujiwara, Beng Chong et al. “Basic Kruppel-like factor recruits multiple co-repressors to silence gene expression.” In 13 th Conference on Hemoglobin Switching, vol. 31, no. 1, pp. 135-136. Academic Press, 2003.
Perkins, Andrew C., Arlene H. Sharpe, and Stuart H. Orkin. “Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF.” (1995): 318-322.
Young, Graham AR, Andrew C. Perkins, Harry J. Iland, Paul C. Vincent, and Ajita Kulkarni. “Late Relapses in Hodgkin’s Disease: Are They a Distinct Entity?.” Leukemia & Lymphoma 4, no. 5-6 (1991): 363-369.