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Projects

Projects in the Perkins Lab

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PhD and Honours Projects – Where do blood stem cells come from?

PhD and Honours Projects – Where do blood stem cells come from?

by Andrew Perkins on May 29, 2019 with No Comments

We are investigating the origins of blood stem cell generation in the embryo. We are interesting in profiling ontogeny and reprogramming non-blood cells into blood cells Origins and ontogeny of blood in the mammalian embryo (Diagram courtesy of JIm Palis, … Read More

Projects
PhD and Honours Projects – Hemoglobin Switching

PhD and Honours Projects – Hemoglobin Switching

by Andrew Perkins on May 29, 2019 with No Comments

Transcriptional Regulation of Haemoglobin switching We employ genomics techniques (ChIp-Seq, RNA-Seq, SLAM-Seq), biochemical techniques (EMSA, SPR) and genetics techniques (CRISPR/CAS9 gene editing) to examine the role of transcription factors in red blood cell differentiation and diseases Supervisors: Kevin Gillinder and … Read More

Projects
PhD and Honours – JAK-STAT signaling in cancer

PhD and Honours – JAK-STAT signaling in cancer

by Andrew Perkins on May 29, 2019 with No Comments
Projects
CRISPR-Cas9 Genome Editing

CRISPR-Cas9 Genome Editing

by Charles Bell on April 9, 2015 with No Comments

CRISPR-Cas9 genome editing is a revolutionary technology that allows rapid and precise modification of the eukaryotic genome. Developed in 2013, the technology has exploded, with over 1000 published articles using the technology. Given the simplicity and efficiency of the technology, our … Read More

Projects, Protocols CRISPR
Understanding the Regulation of Early Mouse Embryonic Development

Understanding the Regulation of Early Mouse Embryonic Development

by Charles Bell on April 9, 2015 with No Comments

In this project theme, our lab is interested in understanding how normal mouse embryonic development is regulated by both transcription factors and long non coding RNAs. Using embryonic stem cells and embryoid body differentiation, a common model of early mouse development, … Read More

Projects CRISPR, Development, embryonic, gastrulation
Recent Posts
  • PhD and Honours Projects – Where do blood stem cells come from?
  • PhD and Honours Projects – Hemoglobin Switching
  • PhD and Honours – JAK-STAT signaling in cancer
  • Targeted Re-sequencing for Diagnosis and Prognosis in MPNs
  • CRISPR-Cas9 Genome Editing
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About Us

The Perkins Lab is interested in how transcription factors control blood development and how mutations can lead to diseases like cancer. Our research also focuses on inherited and acquired disorders of blood cell production including myeloproliferative neoplasms and myelodysplastic syndromes.
We utilize advanced genomic techniques to investigate mechanisms of disease and translate these into potential therapies. If you’d like to find out more about us, please
contact us.

Perkins Lab

Cancer Genomics Lab

Andrew Perkins

Australian Centre for Blood Diseases Monash University, Alfred Hospital, VIC 3004

+61 3 9903 0122

andrew.perkins@monash.edu

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